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There are currently many methods for synthesizing Ferumoxytol, mainly including the following: coprecipitation, hydrothermal reaction, precursor high-temperature pyrolysis, microemulsion, solution-gel, sonochemical reaction, flow injection, and point-jet synthesis. Among these, coprecipitation, hydrothermal reaction, and precursor hydrothermal decomposition are the most commonly used. Precipitation is low-cost, simple in principle, and produces high-purity products; however, its application is limited by the significant influence of the external environment during the reaction process, requiring strict nitrogen protection, and the poor particle size uniformity of the product. Precursor high-temperature pyrolysis can yield Ferumoxytol with good particle size uniformity and dispersibility, but the precursor acquisition method is complex, expensive, and contains toxic substances, limiting its application. Compared to the first two methods, hydrothermal synthesis is more adaptable, with inexpensive raw materials, simple synthesis, controllable reaction conditions, uniform particle size of the synthesized product, and the surface generally possessing various special functional groups for further modification. Therefore, it has gradually become the most commonly used synthesis method for Ferumoxytol. |
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TOSUN PHARM
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