| Identification | Back Directory | [Name]
AZD1152 | [CAS]
722543-31-9 | [Synonyms]
AZD1152
CS-1053
Barasertib (AZD1152)
BARASERTIB; AZD-1152; AZD 1152
5-[[7-[3-[Ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-3-acetamide
1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-
2-[[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)amino]quinazolin-7-yl}oxy)propyl](ethyl)amino]ethyl dihydrogen phosphate | [Molecular Formula]
C26H31FN7O6P | [MDL Number]
MFCD15146330 | [MOL File]
722543-31-9.mol | [Molecular Weight]
587.54 |
| Chemical Properties | Back Directory | [density ]
1.463 | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
insoluble in H2O; insoluble in EtOH; ≥5.88 mg/mL in DMSO | [form ]
solid | [pka]
1.75±0.10(Predicted) |
| Hazard Information | Back Directory | [Definition]
ChEBI: AZT-1152 is a dihydrogen phosphate prodrug of a pyrazoloquinazoline aurora kinase inhibitor AZD1152-hydroxyquinazoline pyrazol anilide(HQPA) and is converted rapidly to the active AZD1152-HQPA in plasma. It has a role as a prodrug, an antineoplastic agent and an Aurora kinase inhibitor. It is a member of quinazolines, a monoalkyl phosphate, an anilide, a member of monofluorobenzenes, a member of pyrazoles, a secondary amino compound, a secondary carboxamide and a tertiary amino compound. It is functionally related to an AZD-1152. |
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NCE Biomedical Co.,Ltd.
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