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Btm 1042 is an antispasmodic drug that has been found to depress twitch responses in the ileum of guinea pig. | [Uses]
BTM-1042 is a newly synthesized compound with antispasmodic effects. It can inhibit the twitch reaction of the guinea pig ileum under electrical stimulation and is not affected by naloxone. It has similar effects to atropine and can block muscarinic receptors, but has less effect on other types of receptors. BTM-1042 also has an inhibitory effect on the ileal reaction caused by nicotine and 5-hydroxytryptamine. BTM-1042 showed a dose-dependent inhibitory effect on the spontaneous movement of the rabbit stomach. In general, BTM-1042 is a agent with a strong antispasmodic effect. | [References]
[1] POSSIBLE MECHANISMS OF A NEW TYPE OF ANTISPASMODIC DRUG, BTM-1042(CIS-(-)-2,3-DIHYDRO 3-(4-METHYL-PIPERAZINYL)METHYL-2-PHENYL-1,5 BENZOTHIAZEPIN-4(5H)-ONE DI HYDROCHLORIDE) |
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