| Identification | Back Directory | [Name]
Pengitoxin | [CAS]
7242-04-8 | [Synonyms]
Pentaacetate
pentaacetylgitoxin
Card-20(22)-enolide, 16-(acetyloxy)-3-[(O-3,4-di-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-14-hydroxy-, (3β,5β,16β)- | [EINECS(EC#)]
230-645-5 | [Molecular Formula]
C51H74O19 | [MOL File]
7242-04-8.mol | [Molecular Weight]
991.12 |
| Chemical Properties | Back Directory | [Melting point ]
151-155° | [alpha ]
D20 +14.0 ±1.5° (c = 1.6 in pyridine) | [Boiling point ]
742.94°C (rough estimate) | [density ]
1.1187 (rough estimate) | [refractive index ]
1.6500 (estimate) | [Water Solubility ]
11.89mg/L(temperature not stated) |
| Hazard Information | Back Directory | [Originator]
Pengitoxin,Shanghai Lansheng | [Manufacturing Process]
Gitoxin is isolated from leaves of Digitalis purpurea L. genus Scrofphulariaceae.
10.0 g pure gitoxin are boiled under reflux with 1 L pure acetic anhydride. Gitoxin thereby goes into solution in the course of 1 h. The boiling is discontinued after 1 h and the acetic anhydride distilled off in a vacuum as completely as possible. After taking up the oily residue with 500 ml chloroform, the solution is successively washed with 200 ml of 2 N potassium bicarbonate solution, 0.1 N hydrochloric acid and water. After drying the chloroform solution with anhydrous sodium sulfate, the chloroform is first distilled off over an open flame and then on a water bath at 40°C in a vacuum, a substantially crystalline residue thereby being obtained. The 12.8 g of crude product obtained are recrystallized from 12 times the amount of a mixture of pyridine, methanol and water (25:10:65) to give rhombic crystals, melting point 151°-155°C. | [Therapeutic Function]
Cardiotonic |
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