| Identification | Back Directory | [Name]
A-381393 | [CAS]
726174-00-1 | [Synonyms]
A-381393
A-381393;A 381393;A381393
1H-Benzimidazole, 2-[[4-(3,4-dimethylphenyl)-1-piperazinyl]methyl]- | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C20H24N4 | [MDL Number]
MFCD32062772 | [MOL File]
726174-00-1.mol | [Molecular Weight]
320.43 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:51.67(Max Conc. mg/mL);161.25(Max Conc. mM) | [form ]
Solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
A-381393 is a potent, selective, brain penetrate dopamine D4 receptor antagonist, with Kis of 1.5, 1.9 and 1.6 nM for human dopamine D4.4, D4.2, and D4.7 receptor, respectively, >2700-fold selectivity over D1, D2, D3 and D5 dopamine receptors. A-381393 shows moderate affinity for 5-HT2A (Ki, 370 nM)[1]. | [IC 50]
D3 Receptor; D4 Receptor | [storage]
Store at -20°C | [References]
[1] Nakane M, et al. 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist. Neuropharmacology. 2005 Jul;49(1):112-21. DOI:10.1016/j.neuropharm.2005.02.004 |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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