| Identification | Back Directory | [Name]
1-Azoniabicyclo[2.2.2]octane, 3-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-1-(3-phenoxypropyl)-, (3R)- | [CAS]
727649-81-2 | [Synonyms]
1-Azoniabicyclo[2.2.2]octane, 3-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-1-(3-phenoxypropyl)-, (3R)- | [Molecular Formula]
C26H30NO4S2+ | [MOL File]
727649-81-2.mol | [Molecular Weight]
484.65 |
| Hazard Information | Back Directory | [Uses]
Aclidinium is a long-acting muscarinic antagonist and long-acting β2-adrenoceptor (β2-AR) agonist with bronchodilator activity. Aclidinium can reduce hyperinflation of the lungs and increase lung function and exercise endurance time. Aclidinium is used in research on chronic obstructive pulmonary disease (COPD)[1]. | [Definition]
ChEBI: Aclidinium is a carboxylic ester obtained by formal condensation between the carboxy group of 2-hydroxy(di-2-thienyl)acetic acid and the hydroxy group of N-(3-phenoxypropyl)-3-quinuclidinol. Used as its bromide salt for the long-term maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD). It has a role as a bronchodilator agent and a muscarinic antagonist. It is a quaternary ammonium ion, a carboxylic ester, a member of thiophenes and an aromatic ether. It is functionally related to a 3-quinuclidinol. | [References]
[1] D’Urzo, et al. "Aclidinium bromide/formoterol fumarate as a treatment for COPD: an update." Expert review of respiratory medicine 15.9 (2021): 1093-1106. DOI:10.1080/17476348.2021.1920403 |
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Biorbyt Ltd.
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+44 (0)1223 859 353 |
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http://www.biorbyt.com |
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