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72809-08-6

72809-08-6 Structure

72809-08-6 Structure
IdentificationBack Directory
[Name]

Oleoyl Serinol
[CAS]

72809-08-6
[Synonyms]

Oleoyl Serinol
N-Oleoyl serinol
N-(1,3-dihydroxypropan-2-yl)oleamide
9-Octadecenamide, N-[2-hydroxy-1-(hydroxymethyl)ethyl]-, (9Z)-
[Molecular Formula]

C21H41NO3
[MOL File]

72809-08-6.mol
[Molecular Weight]

355.56
Chemical PropertiesBack Directory
[solubility ]

DMF: >30 mg/ml; DMSO: >15 mg/ml; Ethanol: >30 mg/ml; PBS (pH 7.2): >290 μg/ml
[form ]

A crystalline solid
Hazard InformationBack Directory
[Uses]

N-Oleoyl serinol is a ceramide analog that can be used in stem cell therapy to prevent stem cells from developing into teratomas. N-Oleoyl serinol induces apoptosis in residual pluripotent embryoid body-derived cells (EBCs), prevents teratoma formation, and enriches EBC cells that undergo neural differentiation after transplantation[1].
[References]

[1] Bieberich E, et al. Selective apoptosis of pluripotent mouse and human stem cells by novel ceramide analogues prevents teratoma formation and enriches for neural precursors in ES cell-derived neural transplants. J Cell Biol. 2004 Nov 22;167(4):723-34. DOI:10.1083/jcb.200405144
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