| Identification | Back Directory | [Name]
GLYCINE-15N | [CAS]
7299-33-4 | [Synonyms]
GLYCINE-15N
[15N]GLYCINE
H-[15N]GLY-OH
[15N]-L-GLYCINE
2-azanylacetic acid
Nitrogen-15 glycine
2-azanylethanoic acid
Glycine-15N
[15N]Glycine
GLYCINE-15N, 99 ATOM % 15N
GLYCINE-(15)N, 98 (ATOM % (15)N)
Glycine labeled with nitrogen-15 | [Molecular Formula]
C2H5NO2 | [MDL Number]
MFCD00064426 | [MOL File]
7299-33-4.mol | [Molecular Weight]
76.08 |
| Chemical Properties | Back Directory | [Melting point ]
240 °C (dec.)(lit.) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
Aqueous Base (Slightly, Sonicated, Heated), Water (Sparingly) | [form ]
Solid | [color ]
White to Off-White | [BRN ]
1853034 | [InChIKey]
DHMQDGOQFOQNFH-LBPDFUHNSA-N | [CAS Number Unlabeled]
56-40-6 |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Uses]
Glycine-15N is the labelled form of Glycine (G615990). Glycine is a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors. | [Biological Activity]
Glycine-15N is the 15N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors[1]. | [IC 50]
NMDA Receptor | [References]
[1] EDWARD M RUSSAK Edward M B. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals.[J]. Annals of Pharmacotherapy, 2019, 53 2: 211-216. DOI:10.1177/1060028018797110.
[2] W. GREENAWAY F. R W. A convenient synthesis of creatine-15N from glycine-15N via sarcosine-15N[J]. Journal of labelled compounds & radiopharmaceuticals, 1978, 14 4: 611-615. DOI:10.1002/jlcr.2580140417.
[3] HE J, ZHANG X, HE Q, et al. Synthesis of 15N-labeled heterocycles via the cleavage of C–N bonds of anilines and glycine-15N†[J]. Chemical Communications, 2021, 44: 5442-5445. DOI:10.1039/D1CC01734A.
[4] T P STEIN. Measurement of protein synthesis rates with [15N]glycine.[J]. American Journal of Physiology, 1980, 239 4: E294-E300. DOI:10.1152/ajpendo.1980.239.4.E294.
[5] MOSTAFA OTHMAN. Millimeter-Sized Clusters of Triple Cation Perovskite Enables Highly Efficient and Reproducible Roll-to-Roll Fabricated Inverted Perovskite Solar Cells[J]. Advanced Functional Materials, 2021, 32 12. DOI:10.1002/adfm.202110700. |
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