| Identification | Back Directory | [Name]
SOMATOSTATIN 28, CYCLIC | [CAS]
73032-94-7 | [Synonyms]
28)-disulfide
Cyclic somatostatin-28
SOMATOSTATIN 28, CYCLIC
Somatostatin 28, ≥97% (HPLC)
M.W. 3148.60 C137H207N41O39S3
SOMATOSTATIN 28, CYCLIC USP/EP/BP
Somatostatin-28 (sheep reduced) cyclic (17-28)-disulfide
H-Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH
Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys ( Cys17-Cys28)
SER-ALA-ASN-SER-ASN-PRO-ALA-MET-ALA-PRO-ARG-GLU-ARG-LYS-ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS(DISULFIDE BRIDGE CYS17-CYS28) | [Molecular Formula]
C137H207N41O39S3 | [MDL Number]
MFCD01632184 | [MOL File]
73032-94-7.mol | [Molecular Weight]
3148.56 |
| Hazard Information | Back Directory | [Hazard]
A poison. | [Uses]
Somatostatin 28 has been used to study the effects of somatostatin in regulating hepatic growth hormone sensitivity. It has also been used to study its effects on insulin-like growth factor-I receptor expression in the gills of Oncorhynchus mykiss (a teleost fish). | [General Description]
The SST gene is mapped to human chromosome 3q27.3. Both SST-14 and SST-28 are cyclic peptide. | [Biochem/physiol Actions]
Somatostatin plays an important role in regulating the metabolism of other hormones such as growth hormone, insulin, IGF-1 (insulin-like growth factor 1), glucagon, glucagon-like peptide and gastrin. Somatostatin has both regulatory and inhibitory functions. It retards gastrointestinal motility and gallbladder contraction, suppresses gut exocrine secretion and reduces epithelial proliferation. Somatostatin is associated with intestinal nutrient absorption and blood flow regulation. This peptide hormone is believed to inhibit cell proliferation and promote apoptosis. Somatostatin acts as a neurotransmitter and neuromodulator, and is also associated in maintaining water balance. | [in vivo]
Somatostatin-28 (sheep) (1.1 pmol/kg/min; i.v. via a jugular catheter; 15 min) inhibits insulin secretion induced by 25 μg/kg/min glucose in sheep[2]. | Animal Model: | Finn-Dorset Horn cross bred sheep (2-5 years old, 70-75 kg)[2] | | Dosage: | 1.1 pmol/kg/min for 15 min, with or without 25 μg/kg/min glucose; | | Administration: | Intravenous injection via a jugular catheter; | | Result: | Significantly inhibited insulin secretion, resulted serum concentrations decreasing from about 200 to 150 pmol/L. |
| [IC 50]
SSTR5 |
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