| Identification | Back Directory | [Name]
SUC-ALA-PHE-LYS-AMC | [CAS]
73207-91-7 | [Synonyms]
Suc-AFK-AMC
SUC-ALA-PHE-LYS-AMC
N-(3-Carboxy-1-oxopropyl)-L-alanyl-L-phenylalanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-lysinamide | [Molecular Formula]
C32H39N5O8 | [MDL Number]
MFCD00038708 | [MOL File]
73207-91-7.mol | [Molecular Weight]
621.68 |
| Chemical Properties | Back Directory | [Boiling point ]
1039.6±65.0 °C(Predicted) | [density ]
1.302±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.69±0.10(Predicted) | [color ]
White to off-white | [Sequence]
{Suc-Ala}-Phe-{Lys-AMC} |
| Hazard Information | Back Directory | [Uses]
Suc-Ala-Phe-Lys-AMC is a highly sensitive fluorogenic substrate for plasmin. Suc-Ala-Phe-Lys-AMC is also used for assaying gingipain K[1][2]. | [References]
[1] P A Pierzchala, et al. A new fluorogenic substrate for plasmin. Biochem J. 1979 Dec 1;183(3):555-9. DOI:10.1042/bj1830555
[2] Marion G G?tz, et al. Aza-peptidyl Michael Acceptors. A New Class of Potent and Selective Inhibitors of Asparaginyl Endopeptidases (Legumains) from Evolutionarily Diverse Pathogens. J Med Chem. 2008 May 8;51(9):2816-32. DOI:10.1021/jm701311r |
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