| Identification | Back Directory | [Name]
Xamoterol hemifumarate | [CAS]
73210-73-8 | [Synonyms]
Corwin
Carwin
Xamtol
XAMOTEROL
ICI-118587
Corwin：Xamtol
Xamoterol hemifumara
XAMOTEROL HEMIFUMARATE
XAMOTEROL HEMIFUMARATE SALT
QEDVGROSOZBGOZ-WXXKFALUSA-N
ICI 118587 HEMIFUMARATE SALT
N-(2-((2-hydroxy-3-(4-hydroxyphenoxy)propyl)aMino)ethyl)Morpholine-4-carboxaMide
1-(4-HYDROXYPHENOXY)-3-[2-(4-MORPHOLINOCARBOXAMIDO)ETHYLAMINO]-2-PROPANOL HEMIFUMARATE
bis[N-[2-[[2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]morpholine-4-carboxamide] fumarate
(+/-)-N-[2-[[HYDROXY-3-(4-HYDROXY)PROPYL]AMINO]ETHYL-4-MORPHOLINECARBOXAMIDE HEMIFUMARATE SALT
ICI 118587 hemifumarate salt, (±)-N-[2-[[Hydroxy-3-(4-hydroxy)propyl]amino]ethyl-4-morpholinecarboxamide hemifumarate salt | [EINECS(EC#)]
277-319-9 | [Molecular Formula]
C36H54N6O14 | [MDL Number]
MFCD00661104 | [MOL File]
73210-73-8.mol | [Molecular Weight]
794.85 |
| Hazard Information | Back Directory | [Description]
Xamoterol fumarate is a cardioselective partial beta-agonist, the first of its class to be
developed for use in heart failure. The main advantage of xamoterol fumarate as a
cardiotonic lies in the fact that its beta-blocking effect exerted during high sympathetic
drive will protect the heart from overstimulation. It is claimed to be a viable but safer
alternative to digoxin. | [Chemical Properties]
Crystallizes in ethanol, melting point 168-169℃ (decomposition). | [Originator]
ICI (United Kingdom) | [Uses]
Stimulant (cardiac). | [Brand name]
Corwin | [Biological Activity]
β 1 -adrenoceptor-selective partial agonist (pA 2 values are 7.4-7.8 and 5.2-6.2 at β 1 - and β 2 -adrenoceptors respectively). | [storage]
Store at RT | [References]
[1] R N WILLETTE. In vitro and in vivo characterization of intrinsic sympathomimetic activity in normal and heart failure rats.[J]. Journal of Pharmacology and Experimental Therapeutics, 1999, 289 1: 48-53.
[2] M T KOWALSKI. Comparison of the effects of xamoterol and isoprenaline on rat cardiac beta-adrenoceptors: studies of function and regulation.[J]. British Journal of Pharmacology, 1990, 99 1: 27-30. DOI: 10.1111/j.1476-5381.1990.tb14648.x
[3] A. NUTTALL H. M S. THE CARDIOVASCULAR EFFECTS OF ICI 118,587: A β1-ADRENOCEPTOR PARTIAL AGONIST[J]. British Journal of Pharmacology, 1982, 77 2: 381-388. DOI: 10.1111/j.1476-5381.1982.tb09309.x |
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