| Identification | Back Directory | [Name]
FR 900098 MonosodiuM Salt | [CAS]
73226-73-0 | [Synonyms]
BRN 2096083
FR900098 (sodium)
FR00098 (sodium salt)
FR900098 (sodium salt)
FR 900098 MonosodiuM Salt
FR900098 sodium salt
(FR 900098)
FR900098 (sodium salt),FR-900098 (sodium salt)
P-[3-(Acetylhydroxyamino)propyl]-phosphonic acid
P-[3-(AcetylhydroxyaMino)propyl]phosphonic Acid SodiuM Salt | [Molecular Formula]
C5H11NNaO5P | [MDL Number]
MFCD17215926 | [MOL File]
73226-73-0.mol | [Molecular Weight]
219.108 |
| Chemical Properties | Back Directory | [Melting point ]
184-186°C | [storage temp. ]
-20°C | [solubility ]
H2O: ≥20mg/mL | [form ]
powder | [color ]
white to light brown | [Water Solubility ]
H2O: ≥20mg/mL | [Stability:]
Hygroscopic | [InChI]
1S/C5H12NO5P.Na/c1-5(7)6(8)3-2-4-12(9,10)11;/h8H,2-4H2,1H3,(H2,9,10,11);/q;+1/p-1 | [InChIKey]
LCFXFDGYDKNWMD-UHFFFAOYSA-M | [SMILES]
[Na+].CC(=O)N(O)CCCP(O)([O-])=O |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Brown Solid | [Uses]
The antibiotics Fosmidomycin and FR900098 are members of a unique class of phosphonic acid natural products that inhibit the nonmevalonate pathway for isoprenoid biosynthesis. Both are potent antibacterial and antimalarial compounds. | [Biochem/physiol Actions]
1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) is an enzyme involved in the first step in the nonmevalonate pathway for isoprenoid biosynthesis in Gram-negative, Gram-positive bacteria, plants, and the parasite causing the most virulent form of malaria, Plasmodium falciparum (Mammals produce isoprenoids via the mevalonate pathway). Inhibiton of the enzyme provides alternative to traditional antimalaria therapy. FR-900098 is twice more effective than fosmidomycin against various strains of P. falciparum in vitro and the closely related P. vinckei in mice. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|