| Identification | Back Directory | [Name]
Deoxynojirimycin hydrochloride | [CAS]
73285-50-4 | [Synonyms]
DNJ
DNM
DNM1
1-DNJ
AT 2220
DNJ, HCL
B-dynamin
Dynamin BREDNM19
DEOXYNOJIRIMICIN
DEOXYNOJIRIMYCIN
DNJ Hydrochloride
DeoxynojirimycinHCl
DNJ，1-Deoxynojirimycin
Moranoline Hydrochloride
Duvoglustat Hydrochloride
DEOXYNOJIRIMYCIN HYDROCHLORIDE
1-DEOXYNOJIRIMYCIN HYDROCHLORIDE
(+)-1-DEOXYNOJIRIMYCIN HYDROCHLORIDE
1,5-DIDEOXY-1,5-IMINO-D-SORBITOL HYDROCHLORIDE
1,5-DIDEOXY-1,5-IMINO-D-GLUCITOL HYDROCHLORIDE
(2R,3R,4R,5S)-2-(HYDROXYMETHYL)-3,4,5-PIPERIDINETRIOL
Anti-Dynamin-1, C-Terminal antibody produced in rabbit
(2R,3R,4R,5S)-2-(hydroxyMethyl)piperidine-3,4,5-triol hydrochloride
(2R,3R,4R,5S)-2-(HydroxyMethyl)-3,4,5-piperidinetriol Hydrochloride
3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, hydrochloride, (2R,3R,4R,5S)-
1-Deoxynojirimycin hydrochloride,1,5-Dideoxy-1,5-imino-D-sorbitol hydrochloride | [Molecular Formula]
C6H13NO4 | [MDL Number]
MFCD00063474 | [MOL File]
73285-50-4.mol | [Molecular Weight]
163.17 |
| Chemical Properties | Back Directory | [Appearance]
White Crystalline Solid | [Melting point ]
195-196°C | [storage temp. ]
2-8°C
| [solubility ]
Water (Slightly) | [form ]
Powder | [color ]
White | [Water Solubility ]
Soluble in water at 20mg/ml | [BRN ]
3563225 | [Stability:]
Hygroscopic | [InChI]
InChI=1/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4+,5-,6-;/s3 | [InChIKey]
ZJIHMALTJRDNQI-KOVNLEGCNA-N | [SMILES]
C([C@H]1NC[C@@H]([C@H]([C@@H]1O)O)O)O.Cl |&1:1,4,5,6,r| | [CAS DataBase Reference]
73285-50-4 |
| Hazard Information | Back Directory | [Chemical Properties]
White Crystalline Solid | [Uses]
Deoxynojirimycin inhibits mammalian glucosidase 1. As well, it inhibits intestinal and lysosmal alpha-glucosidases, beta-glucosidase from sweet almonds, pancreatic alpha-amylase and amyloglucosidase. | [Uses]
natural chitin synthase inhibitor | [Description]
1-Deoxynojirimycin (1-DNJ) is an iminosugar that has been found in M. alba (mulberry) leaves and has diverse biological activities.1,2,3,4,5,6 It inhibits the activities of α- and β-glucosidase (IC50s = 35 and 71 μM, respectively).2 1-DNJ (5 mM) reduces the formation of N-linked complex oligosaccharides in IEC-6 cells.3 It inhibits HIV-1 envelope-mediated membrane fusion in CEM cells when used at a concentration of 2 mM.4 1-DNJ (1-100 μg/ml) reduces the invasion and migration of B16/F10 mouse melanoma cells.5 It improves glucose and insulin tolerance in db/db mice when administered intravenously at doses ranging from 20 to 80 mg/kg per day for four weeks.6 | [General Description]
Specific glucosidase inhibitor, including trimming glucosidases I and II, that sequentially removes the three glucose residues from precursor Glc3Man9GlcNAc2 in N-linked glycan biosynthesis. | [Biochem/physiol Actions]
Product does not compete with ATP. | [storage]
Store at -20°C | [References]
[1] KUO GAO. 1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing.[J]. Molecules, 2016, 21 1. DOI: 10.3390/molecules21111600
[2] ANA I AHUJA-CASARíN. Tuning the activity of iminosugars: novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitors.[J]. Journal of Enzyme Inhibition and Medicinal Chemistry, 2021: 138-146. DOI: 10.1080/14756366.2020.1847101
[3] JULIAN A. CODELLI. Second-Generation Difluorinated Cyclooctynes for Copper-Free Click Chemistry[J]. Journal of the American Chemical Society, 2008, 130 34: 11486-11493. DOI: 10.1021/ja803086r
[4] MARIE-JEANNE PAPANDRéOU. The alpha-glucosidase inhibitor 1-deoxynojirimycin blocks human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step.[J]. Molecular Pharmacology, 2002, 61 1 1: 186-193. DOI: 10.1124/mol.61.1.186
[5] RAN-JUH WANG Miao L H Chun Hung Yang. 1-Deoxynojirimycin Inhibits Metastasis of B16F10 Melanoma Cells by Attenuating the Activity and Expression of Matrix Metalloproteinases-2 and -9 and Altering Cell Surface Glycosylation[J]. Journal of Agricultural and Food Chemistry, 2010, 58 16: 8988-8993. DOI: 10.1021/jf101401b
[6] QINGPU LIU. 1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice.[J]. Molecules, 2015, 20 1: 21700-21714. DOI: 10.3390/molecules201219794 |
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