| Identification | Back Directory | [Name]
5-ETHYL-2,4-PIPERIDINEDIONE | [CAS]
73290-32-1 | [Synonyms]
5-ETHYL-2,4-PIPERIDINEDIONE
5-Ethylpiperidine-2,4-dione
2,4-Piperidinedione, 5-ethyl-
5-Ethyl-2, 4-piperidinedione - [E14290] | [Molecular Formula]
C7H11NO2 | [MDL Number]
MFCD09999166 | [MOL File]
73290-32-1.mol | [Molecular Weight]
141.17 |
| Chemical Properties | Back Directory | [Melting point ]
72-74 °C | [Boiling point ]
156-157 °C(Press: 1 Torr) | [density ]
1.060±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [pka]
12.04±0.70(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of 5-ethyl-2,4-piperidinedione from 1-Boc-5-ethyl-2,4-dioxopiperidine was as follows: 1-Boc-5-ethyl-2,4-dioxopiperidine was dissolved in trifluoroacetic acid (TFA, 10 mL), and the reaction was stirred for 2 h at room temperature. After completion of the reaction, the solvent was removed by rotary evaporator and the resulting residue was purified by column chromatography (eluent: hexane/ethyl acetate, 1:2, v/v) to afford 5-ethylpiperidine-2,4-dione in 52% yield. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-D6): δ 0.89 (t, J = 7.56 Hz, 3H), 1.35 (m, 1H), 1.69 (m, 1H), 2.39 (m, 1H), 3.14-3.38 (m, 4H), 8.05 (s, 1H); ESI (+) MS: m/z 142 (MH+) . | [References]
[1] Patent: US2007/142414, 2007, A1. Location in patent: Page/Page column 18
[2] Synthesis, 2007, # 20, p. 3185 - 3190 |
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SynAsst Chemical.
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www.chemicalbook.com/ShowSupplierProductsList15848/0_EN.htm |
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