| Identification | Back Directory | [Name]
EGFR Inhibitor III | [CAS]
733009-42-2 | [Synonyms]
EGFR Inhibitor III
EGFR Inhibitor III - CAS 733009-42-2 - Calbiochem
Acetamide, 2-chloro-N-[4-[(4,5-dichloro-2-fluorophenyl)amino]-6-quinazolinyl]- | [Molecular Formula]
C16H10Cl3FN4O | [MDL Number]
MFCD28138116 | [MOL File]
733009-42-2.mol | [Molecular Weight]
399.63 |
| Chemical Properties | Back Directory | [Melting point ]
>300 °C | [Boiling point ]
566.7±50.0 °C(Predicted) | [density ]
1.607±0.06 g/cm3(Predicted) | [storage temp. ]
-20C | [solubility ]
DMSO: 100mg/mL (Use fresh, anhydrous DMSO.) | [form ]
Yellow solid | [pka]
11.18±0.43(Predicted) | [color ]
yellow |
| Hazard Information | Back Directory | [Uses]
EGFR Inhibitor III is which inhibits EGFR- kinase activity, blocking phosphorylation. | [General Description]
A cell-permeable quinazolinyl-chloroacetamide compound that selectively and irreversibly blocks EGFR autophosphorylation with no effect on the expression levels of EGFR, and suppresses leiomyoma and myometrical cell proliferation (IC50 = 0.7 μM and 1.1 μM, respectively). Shown to induce apoptosis and cell cycle arrest, and in combination with Genistein (Cat. No. 345834) completely suppress leiomyoma cell proliferation. | [Biochem/physiol Actions]
Target IC50: 0.7 μM and 1.1 μM suppressesing leiomyoma and myometrical cell proliferation, respectively |
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| Company Name: |
Sigma-Aldrich
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| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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