| Identification | Back Directory | [Name]
Amcinafide | [CAS]
7332-27-6 | [Synonyms]
Amcinafide
9-Fluoro-11β,21-dihydroxy-16α,17-[[(R)-1-phenylethylidene]bis(oxy)]pregna-1,4-diene-3,20-dione | [Molecular Formula]
C29H33FO6 | [MOL File]
7332-27-6.mol | [Molecular Weight]
496.57 |
| Chemical Properties | Back Directory | [Boiling point ]
650.507±55.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.353±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
12.865±0.10(predicted) |
| Hazard Information | Back Directory | [Originator]
Amcinafide,Onbio Inc. | [Uses]
Anti-inflammatory. | [Manufacturing Process]
1 ml 72% perchloric acid was added to a suspension of 4 g triamcinolone in
100 ml of fresh distilled acetophenone and the mixture was stirred at a room
temperature before all triamcinolone solved (for about 2 hours). The solution
was neutralized with help of 8 ml of 1.1 N sodium hydroxide and sufficient
quantity of sodium bicarbonate. Then chloroform and water were added.
Organic layer was separated and concentrated in vacuum. The residue was
recrystallized from acetone-hexane and thoroughly washed from
acetophenone with hexane. Triamcinolone acetophenide (amicinafide) was
prepared. It had MP: 281°-283°C (decomp.);αD
23 = +23°. (c = 0.98 in
CHCl3). | [Therapeutic Function]
Antiinflammatory, Antiallergic |
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