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73360-56-2

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73360-56-2 Structure

73360-56-2 Structure
IdentificationBack Directory
[Name]

5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide monohydrate
[CAS]

73360-56-2
[Synonyms]

Cestocide
Zestocarp
2',5-D733ichloro-4'-nitrosalicylanilide Hydrate
N-(2-Chloro-4-nitrophenyl)-5-chlorosalicylaMide Hydrate
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzaMide Hydrate
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide monohydrate
[Molecular Formula]

C13H8Cl2N2O4.H2O
[MDL Number]

MFCD16620468
[MOL File]

73360-56-2.mol
[Molecular Weight]

345.14
Chemical PropertiesBack Directory
[Melting point ]

224-229℃
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

neat
Safety DataBack Directory
[Symbol(GHS) ]

Environment (GHS09)
GHS09
[Signal word ]

Warning
[Hazard statements ]

H400
[Precautionary statements ]

P273
[Hazard Codes ]

N
[Risk Statements ]

50
[Safety Statements ]

61
[RIDADR ]

UN 3077 9 / PGIII
[WGK Germany ]

2
[RTECS ]

VN8400000
Hazard InformationBack Directory
[Uses]

5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide monohydrate is used as an anthelmintic drug (Cestodes).
[in vivo]

Niclosamide monohydrate (oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks) treatment inhibits adrenocortical carcinoma tumor growth in vivo[3].

Animal Model:Nu+/Nu+ mice injected with NCI-H295R cells[3]
Dosage:100 mg/kg, 200 mg/kg
Administration:Oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks
Result:Showed a 60%-80% inhibition in tumor growth, as compared to the control group.
[IC 50]

STAT3: 0.25 μM (IC50, in HeLa cells)
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