| Identification | Back Directory | [Name]
COH-SR4
(Mitochondria uncoupler SR4) | [CAS]
73439-19-7 | [Synonyms]
COH-SR4
Urea, N,N'-bis(3,5-dichlorophenyl)-
COH-SR4
(Mitochondria uncoupler SR4)
anticancer,anti-proliferative,kinase,leukemia,protein,breast,cancers,lung,COH SR4,COHSR4,anti-adipogenic,COH-SR-4,Inhibitor,AMPK,melanoma,inhibit,COH-SR4,AMP-activated protein kinase,AMP-activated | [Molecular Formula]
C13H8Cl4N2O | [MDL Number]
MFCD01566238 | [MOL File]
73439-19-7.mol | [Molecular Weight]
350.03 |
| Chemical Properties | Back Directory | [Melting point ]
298-300 °C | [Boiling point ]
363.2±42.0 °C(Predicted) | [density ]
1.608±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 125 mg/mL (357.11 mM; Need ultrasonic) | [form ]
Solid | [pka]
12.42±0.70(Predicted) | [color ]
White |
| Hazard Information | Back Directory | [Uses]
N,N'-Bis(3,5-dichlorophenyl)-urea is a by-product during the synthesis of Vinclozolin (V314050), which is an agricultural fungicide. | [Biological Activity]
Cell permeable: yes | [in vivo]
COH-SR4 (5 mg/kg; i.g.; 3x/week; for 6 weeks) reduces body weight and fat mass in high fat diet (HFD) obese mice without affecting food intake[2].
COH-SR4 improves glycemic control and dyslipidemia in HFD obese mice[2].
COH-SR4 decreases adipose tissue hypertrophy and affects circulating adipokine levels in HFD obese mice[2].
COH-SR4 prevents hepatic lipid accumulation and fatty liver in HFD obese mice[2].
| Animal Model: | Nine-week old male C57BL/6J mice[2] | | Dosage: | 5 mg/kg | | Administration: | Oral gavage, three times a week, for 6 weeks | | Result: | Decreased body weight and fat mass in HFD obese mice. |
| [storage]
Store at -20°C |
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