73544-48-6

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73544-48-6 Structure

Identification	Back Directory
[Name] 7-acetyllycopsamine
[CAS] 73544-48-6
[Synonyms] Acetyllycopsamine 7-ACETYLLYCOPSAMINE 7-O-Acetyllycopsamine from Symphytum Butanoic acid, 2,3-dihydroxy-2-(1-methylethyl)-, [(1R,7aR)-1-(acetyloxy)-2,3,5,7a-tetrahydro-1H-pyrrolizin-7-yl]methyl ester, (2S,3S)-
[Molecular Formula] C17H27NO6
[MDL Number] MFCD32061904
[MOL File] 73544-48-6.mol
[Molecular Weight] 341.4

Chemical Properties	Back Directory
[Occurrence] A minor pyrrolizidine alkaloid, this base has been isolated from Symphytum uplandicum.

Hazard Information	Back Directory
[Uses] 7-Acetyllycopsamine, a pyrrolizidine alkaloid, is a mild hepatotoxin. 7-Acetyllycopsamine can induce liver inflammation in mice[1].
[Definition] ChEBI: Acetyllycopsamine is a member of pyrrolizines.
[in vivo] 7-Acetyllycopsamine (750 mg/kg; single dose) induces liver inflammation, detectable as significantly greater serum ALT (alanine transaminase) scores than controls in C57BL/6J male mice^[1].
[References] [1] Oliver Robinson, et al. Hirmi Valley liver disease: a disease associated with exposure to pyrrolizidine alkaloids and DDT. J Hepatol. 2014 Jan;60(1):96-102. DOI:10.1016/j.jhep.2013.07.039

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