| Identification | Back Directory | [Name]
Benzenemethanaminium, 3,3'-azobis[N,N,N-trimethyl-, diiodide (9CI) | [CAS]
73711-18-9 | [Synonyms]
Benzenemethanaminium, 3,3'-azobis[N,N,N-trimethyl-, diiodide (9CI) | [Molecular Formula]
C20H30IN4+ | [MOL File]
73711-18-9.mol | [Molecular Weight]
453.39 |
| Hazard Information | Back Directory | [Description]
BisQ is a photochromic agonist for the muscle-type nAChR. | [Uses]
Bis-Q is an acetylcholine (ACh) agonist that targets voltage-clamped muscle fibers of the fish Xenomystus nigris. Bis-Q exists in two forms: cis-Bis-Q (non-agonist) and trans-Bis-Q (agonist). Photoisomerization converts cis-Bis-Q to trans-Bis-Q, which induces agonist-induced currents. Channels activated by trans-Bis-Q and ACh have similar conductances and open times. Flashes increase the ratio of trans-Bis-Q to cis-Bis-Q until light equilibrium is reached. Further flashes transiently increase agonist-induced currents, indicating binding of trans-Bis-Q to desensitized receptors. Higher concentrations of cis-Bis-Q produce larger agonist-induced currents that decay exponentially.[1]. | [References]
[1] Activation and desensitization of acetylcholine receptors in fish muscle with a photoisomerizable agonist. |
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