| Identification | Back Directory | [Name]
alpha-monofluoromethyl-4-tyrosine | [CAS]
73804-76-9 | [Synonyms]
Tyrosine, α-(fluoromethyl)-
alpha-monofluoromethyl-4-tyrosine | [Molecular Formula]
C10H12FNO3 | [MOL File]
73804-76-9.mol | [Molecular Weight]
213.21 |
| Chemical Properties | Back Directory | [Boiling point ]
418.2±45.0 °C(Predicted) | [density ]
1.353±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear (warmed) | [form ]
powder | [pka]
1.53±0.16(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Biological Activity]
A racemic mixture of D- and L-AFMT. L-AFMT is reported to selectively inhibt against gut bacteria E. faecalis pyridoxal-5μ-phosphate (PLP)-dependent tyrosine decarboxylase (TyrDC)-but not aromatic amino acid decarboxylase (AADC)-mediated L-dopa decarboxylation (IC50 = 4.7 μM/cell-free1.4 μM/in E. faecalis cultures; 20% human AADC inhibition at 650 μM) via covalent adduct formation with TyrDC co-factor PLP. When co-administered with L-dopa (10 mg/kg) and the AADC inhibitor carbidopa (30 mg/kg) to gnotobiotic mice colonized with E. faecalisL-AFMT (25 mg/kg) significantly increases L-dopa peak serum concentration. |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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