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7403-44-3

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7403-44-3 Structure

7403-44-3 Structure
IdentificationBack Directory
[Name]

P18IN 005
[CAS]

7403-44-3
[Synonyms]

P18IN005
P18IN 005
P18IN005 HCl
P18IN-005 HCl
[Molecular Formula]

C19H24ClNO2
[MOL File]

7403-44-3.mol
[Molecular Weight]

333.86
Hazard InformationBack Directory
[Description]

P18IN005 HCl is a novel p18(INK4C) inhibitor.
[Uses]

P18IN005 hydrochloride is a novel inhibitor of p18, exhibiting potent activity in negatively regulating haematopoietic stem cell (HSC) self-renewal. P18IN005 hydrochloride has been shown to be more effective than p27 in inhibiting HSC self-renewal in mouse models. P18IN005 hydrochloride promotes the expansion of functional HSCs in short-term cultures. P18IN005 hydrochloride serves as a valuable tool for dissecting the signaling pathways involved in stem cell self-renewal.
[References]

[1] Small-molecule inhibitors targeting INK4 protein p18(INK4C) enhance ex vivo expansion of haematopoietic stem cells DOI:10.1038/ncomms7328
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