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741730-12-1

741730-12-1 Structure

741730-12-1 Structure
IdentificationBack Directory
[Name]

ASP-ASP-CYS-GLY-LYS-LEU-PHE-SER-GLY-CYS-ASP-THR-ASN-ALA-ASP-CYS-CYS-GLU-GLY-TYR-VAL-CYS-ARG-LEU-TRP-CYS-LYS-LEU-ASP-TRP
[CAS]

741730-12-1
[Synonyms]

HETEROPODATOXIN-2
ASP-ASP-CYS-GLY-LYS-LEU-PHE-SER-GLY-CYS-ASP-THR-ASN-ALA-ASP-CYS-CYS-GLU-GLY-TYR-VAL-CYS-ARG-LEU-TRP-CYS-LYS-LEU-ASP-TRP
[Molecular Formula]

C144H212N38O47S6
[MDL Number]

MFCD06201850
[MOL File]

741730-12-1.mol
[Molecular Weight]

3419.84
Chemical PropertiesBack Directory
[density ]

1.588±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[storage temp. ]

−20°C
[form ]

lyophilized powder
[Sequence]

Asp-Asp-Cys-Gly-Lys-Leu-Phe-Ser-Gly-Cys-Asp-Thr-Asn-Ala-Asp-Cys-Cys-Glu-Gly-Tyr-Val-Cys-Arg-Leu-Trp-Cys-Lys-Leu-Asp-Trp-NH2 (Disulfide bridge:Cys3-Cys17;Cys10-Cys22;Cys16-Cys26)
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

Heteropodatoxin-2, a peptides of 30-amino acid, is a heteropodatoxin. Heteropodatoxin-2 blocks Kv4.2 current expressed in Xenopus laevis oocytes in a voltage-dependent manner, with less block at more positive potentials[1].
[References]

[1] M C Sanguinetti, et al. Heteropodatoxins: peptides isolated from spider venom that block Kv4.2 potassium channels. Mol Pharmacol. 1997 Mar;51(3):491-8. PMID:9058605
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