| Identification | Back Directory | [Name]
ASP-ASP-CYS-GLY-LYS-LEU-PHE-SER-GLY-CYS-ASP-THR-ASN-ALA-ASP-CYS-CYS-GLU-GLY-TYR-VAL-CYS-ARG-LEU-TRP-CYS-LYS-LEU-ASP-TRP | [CAS]
741730-12-1 | [Synonyms]
HETEROPODATOXIN-2 ASP-ASP-CYS-GLY-LYS-LEU-PHE-SER-GLY-CYS-ASP-THR-ASN-ALA-ASP-CYS-CYS-GLU-GLY-TYR-VAL-CYS-ARG-LEU-TRP-CYS-LYS-LEU-ASP-TRP | [Molecular Formula]
C144H212N38O47S6 | [MDL Number]
MFCD06201850 | [MOL File]
741730-12-1.mol | [Molecular Weight]
3419.84 |
| Chemical Properties | Back Directory | [density ]
1.588±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [storage temp. ]
−20°C | [form ]
lyophilized powder | [Sequence]
Asp-Asp-Cys-Gly-Lys-Leu-Phe-Ser-Gly-Cys-Asp-Thr-Asn-Ala-Asp-Cys-Cys-Glu-Gly-Tyr-Val-Cys-Arg-Leu-Trp-Cys-Lys-Leu-Asp-Trp-NH2 (Disulfide bridge:Cys3-Cys17;Cys10-Cys22;Cys16-Cys26) |
| Hazard Information | Back Directory | [Uses]
Heteropodatoxin-2, a peptides of 30-amino acid, is a heteropodatoxin. Heteropodatoxin-2 blocks Kv4.2 current expressed in Xenopus laevis oocytes in a voltage-dependent manner, with less block at more positive potentials[1]. | [References]
[1] M C Sanguinetti, et al. Heteropodatoxins: peptides isolated from spider venom that block Kv4.2 potassium channels. Mol Pharmacol. 1997 Mar;51(3):491-8. PMID:9058605 |
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