ChemicalBook--->CAS DataBase List--->74417-44-0

74417-44-0

74417-44-0 Structure

74417-44-0 Structure
IdentificationBack Directory
[Name]

1-BROMOMETHYL-ISOQUINOLINE
[CAS]

74417-44-0
[Synonyms]

1-BROMOMETHYL-ISOQUINOLINE
Isoquinoline, 1-(bromomethyl)-
[Molecular Formula]

C10H8BrN
[MDL Number]

MFCD06657041
[MOL File]

74417-44-0.mol
[Molecular Weight]

222.08
Chemical PropertiesBack Directory
[Melting point ]

56℃
[Boiling point ]

322.1±17.0 °C(Predicted)
[density ]

1.518
[storage temp. ]

under inert gas (nitrogen or Argon) at 2-8°C
[pka]

3.90±0.30(Predicted)
[Appearance]

Pale purple to purple Solid
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H319
[Precautionary statements ]

P305+P351+P338
Hazard InformationBack Directory
[Synthesis]

1-METHYLISOQUINOLINE

1721-93-3

1-BROMOMETHYL-ISOQUINOLINE

74417-44-0

The general procedure for the synthesis of 1-(bromomethyl)isoquinoline from 1-methylisoquinoline is as follows: 1. 1-methylisoquinoline (0.99 g, 6.91 mmol), N-bromosuccinimide (NBS, 1.35 g, 1.1 eq.), azobisisobutyronitrile (AIBN, 10 mg, catalytic amount), and carbon tetrachloride (CCl4, 1 mL) were added to a reaction flask. 2. The reaction mixture was heated to reflux for 2 hours. 3. Upon completion of the reaction, the suspended solid particles were removed by filtration and the solids were washed with a small amount of CCl4. 4. The filtrate and washings were combined and concentrated under reduced pressure to remove the solvent. 5. The crude product was purified by column chromatography (eluent: 30% ethyl acetate/hexane) to afford 1-(bromomethyl)isoquinoline (270 mg, yield: 18%) as a violet solid. 6. The structure of the product was determined by 1H-1H-quinolysis. 6. The structure of the product was confirmed by 1H-NMR (500 MHz, CDCl3): δ 8.48 (d, 1H), 8.25 (d, 1H), 7.87 (d, 1H), 7.75-7.67 (m, 2H), 7.65 (d, 1H).

[References]

[1] Patent: WO2008/16239, 2008, A1. Location in patent: Page/Page column 57-58
74417-44-0 suppliers list
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com/
Company Name: LEAP CHEM CO., LTD.
Tel: +86-852-30606658
Website: www.leapchem.com
Company Name: LEAPCHEM CO., LTD.
Tel: +86-852-30606658
Website: www.leapchem.com
Company Name: Aladdin Scientific
Tel:
Website: www.aladdinsci.com/
Company Name: DAYANG CHEM (HANGZHOU) CO.,LTD
Tel: +86-88938639 +86-17705817739 , +86-17705817739
Website: www.dycnchem.com
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Website: http://www.amadischem.com
Company Name: J & K SCIENTIFIC LTD.  
Tel: 18210857532
Website: www.jkchemical.com
Company Name: Shanghai Shenyue Chemical Co., Ltd.  
Tel: 021-68153309 18049974220
Website: http://www.nuohey.com
Company Name: Amber MolTech LLC  
Tel: 086-010-62176588
Website: www.jyamber.com
Company Name: Shanghai Jian Chao Chemical Technology Co., Ltd.  
Tel: 0-1502103-5486 18017383231
Website: http://www.antaeus-e.com/
Company Name: SynAsst Chemical.  
Tel: 021-60343070
Website: www.chemicalbook.com/ShowSupplierProductsList15848/0_EN.htm
Company Name: ShangHai AmK Pharmaceutical Technology Co., Ltd.  
Tel: 18019252918
Website: www.amkchem.com
Company Name: Zhengzhou Guancheng Laboratory equipment Sales  
Tel: 0371-88888888 272369594
Website: www.chemicalbook.com/ShowSupplierProductsList16848/0_EN.htm
Company Name: Aikon International Limited  
Tel: 025-66113011 13155353615
Website: www.aikonchem.com
Company Name: Shanghai WangFa Chemical Technology Co., Ltd.  
Tel: 13918479294
Website: www.chemicalbook.com/ShowSupplierProductsList30419/0_EN.htm
Company Name: Suzhou Nuoouman Biological Technology Co., Ltd.  
Tel: 15026866316
Website: www.nompharm.com/
Company Name: SHANGHAI FDC-CHEMICAL CO.,LTD  
Tel: 021-61469567 13482353728
Website: http://www.fdc-chemical.com/
Company Name: Rhawn Reagent  
Tel: 400-400-1332688 18019345275
Website: http://www.rhawn.cn
Tags:74417-44-0 Related Product Information

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.