| Identification | Back Directory | [Name]
SAM-315 | [CAS]
744218-85-7 | [Synonyms]
SAM-315
WAY-255315
3-naphthalen-1-ylsulfonyl-5-piperazin-1-yl-2H-indazole | [Molecular Formula]
C21H20N4O2S | [MDL Number]
MFCD18782706 | [MOL File]
744218-85-7.mol | [Molecular Weight]
392.47 |
| Hazard Information | Back Directory | [Uses]
SAM-315 (WAY-255315) is a potent antagonist of 5-Hydroxytryptamine-6, with Ki and IC50 of 1.1 nM and 4.6 nM, respectively. SAM-315 significantly increases acetylcholine and glutamate release in hippocampus of the brain[1]. | [IC 50]
5-HT6 Receptor: 4.6 nM (IC50) | [References]
[1] 5-Piperazinyl-3-sulfonylindazoles as Potent and Selective 5-Hydroxytryptamine-6 Antagonists
J. Med. Chem., Article ASAP
DOI: 10.1021/jm1007825
Publication Date (Web): October 8, 2010
[2] Kevin G Liu, et al. 5-Piperazinyl-3-sulfonylindazoles as Potent and Selective 5-Hydroxytryptamine-6 Antagonists. J Med Chem. 2010 Nov 11;53(21):7639-46. DOI:10.1021/jm1007825 |
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