| Identification | Back Directory | [Name]
AH-22921X | [CAS]
74480-23-2 | [Synonyms]
AH-22921X
[1α(Z),2β,5α]-(+/-)-7-[5-[[(1,1'-biphenyl)-4-yl]methoxy]-2-(4-morpholinyl)-3-oxocyclopentyl]-5-heptenoic acid
5-Heptenoic acid, 7-[(1R,2R,5S)-5-([1,1'-biphenyl]-4-ylmethoxy)-2-(4-morpholinyl)-3-oxocyclopentyl]-, (5Z)-rel- | [Molecular Formula]
C29H35NO5 | [MOL File]
74480-23-2.mol | [Molecular Weight]
477.59 |
| Hazard Information | Back Directory | [Uses]
AH22921 is an EP4 prostaglandin receptor antagonist with the activity of antagonizing the activation of adenylate cyclase by prostaglandins in CHO cells. AH22921 can shift the PGE2 concentration-response curve to the right in CHO cells. It is a non-competitive antagonist that is selective for EP4 receptors and has an antagonistic effect on EP4 receptors in CHO cells, but does not affect the PGE2 concentration-response curve in NPE cells containing EP2 receptors. | [References]
[1] Endogenous EP4 prostaglandin receptors coupled positively to adenylyl cyclase in Chinese hamster ovary cells: pharmacological characterization DOI:10.1054/plef.1999.0120 |
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