| Identification | Back Directory | [Name]
PROSTAGLANDIN F3ALPHA | [CAS]
745-64-2 | [Synonyms]
PGF3α
Prostaglandin F3α
PROSTAGLANDIN F3ALPHA
9ALPHA,11ALPHA,15S-TRIHYDROXY-PROSTA-5Z,13E,17Z-TRIEN-1-OIC ACID
(5Z,13E,15S,17Z)-9α,11α,15-Trihydroxyprosta-5,13,17-trien-1-oic acid
(5Z,9S,11R,13E,15S,17Z)-9,11,15-Trihydroxy-5,13,17-prostatriene-1-oic acid
Prosta-5,13,17-trien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9α,11α,13E,15S,17Z)-
(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S,5Z)-3-hydroxyocta-1,5-dienyl]cyclopentyl]hept-5-enoic acid | [Molecular Formula]
C20H32O5 | [MDL Number]
MFCD00135256 | [MOL File]
745-64-2.mol | [Molecular Weight]
352.47 |
| Chemical Properties | Back Directory | [Boiling point ]
541.7±50.0 °C(Predicted) | [density ]
1.171±0.06 g/cm3(Predicted) | [solubility ]
10 mM Na2CO3: >6.5 mg/ml (from PGF2a); DMF: >100 mg/ml (from PGF2a); DMSO: >100 mg/ml (from PGF2a); Ethanol: >100 mg/ml (from PGF2a); PBS pH 7.2: >10 mg/ml (from PGF2a) | [pka]
4.76±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
Prostaglandin F3α (PGF3α) is an eicosapentaenoic acid (EPA)-derived bioactive lipid mediator that has anti-cancer and anti-inflammatory effects. Prostaglandin F3α is a substrate of ABCC4 with a Km of 12.1 μM. Prostaglandin F3α can be used for the research of diabetes[1][2]. | [Definition]
ChEBI: Prostaglandin F3alpha is a prostaglandin Falpha that is prosta-5,13,17-trien-1-oic acid carrying three hydroxy substituents at positions 9alpha, 11alpha and 15. It is a conjugate acid of a prostaglandin F3alpha(1-). | [References]
[1] Tanaka N, et al. Transport of eicosapentaenoic acid-derived PGE?, PGF(3α), and TXB? by ABCC4. PLoS One. 2014 Oct 2;9(10):e109270. DOI:10.1371/journal.pone.0109270
[2] Sailaja Devi MM, et al. Effect of prostaglandins against alloxan-induced diabetes mellitus. Prostaglandins Leukot Essent Fatty Acids. 2006 Jan;74(1):39-60. DOI:10.1016/j.plefa.2005.09.003 |
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