| Identification | Back Directory | [Name]
Ro 363 | [CAS]
74513-77-2 | [Synonyms]
Ro 363
4-(3-(3,4-dimethoxyphenethylamino)-2-hydroxypropoxy)benzene-1,2-diol
1,2-Benzenediol, 4-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-hydroxypropoxy]- | [Molecular Formula]
C19H25NO6 | [MDL Number]
MFCD05662299 | [MOL File]
74513-77-2.mol | [Molecular Weight]
363.4 |
| Hazard Information | Back Directory | [Uses]
Ro 363, an effective inotropic stimulant, is a potent and highly selective β1-adrenoceptor agonist. RO 363 is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility[1][2][3]. | [in vivo]
In chloralose-anaesthetized cats, Ro 363, when compared to epinephrine (adrenaline), is essentially devoid of arrhythmogenic activity in animals in which cardiac sensitization is induced by U-0882 or halothane[1]. | [References]
[1] Maccarrone C, et al. Comparison of the Arrhythmogenic Actions of (-)-Isoprenaline, Dobutamine and the selective beta 1-adrenoceptor agonist, (+/-)-(1-[3',4'-dihydroxyphenoxy] -2-hydroxy-[3",4"-dimethoxy phenethylamino]-propane)-oxalate (Ro 363). Arzneimit PMID:2859864
[2] Iakovidis D, et al. In vitro activity of RO363, a beta1-adrenoceptor selective agonist. Br J Pharmacol. 1980 Apr;68(4):677-85. DOI:10.1111/j.1476-5381.1980.tb10860.x
[3] Einstein R, et al. Comparison of the cardiac effects of beta-adrenoreceptor agonists in anaesthetised and conscious dogs. J Auton Pharmacol. 1986 Mar;6(1):9-14. DOI:10.1111/j.1474-8673.1986.tb00625.x |
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