| Identification | Back Directory | [Name]
5-Hexyn-2-one, 1-(triphenylphosphoranylidene)- | [CAS]
74763-44-3 | [Synonyms]
5-Hexyn-2-one, 1-(triphenylphosphoranylidene)- | [Molecular Formula]
C24H21OP | [MOL File]
74763-44-3.mol | [Molecular Weight]
356.4 |
| Chemical Properties | Back Directory | [Boiling point ]
521.8±52.0 °C(predicted) | [density ]
1.14±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [solubility ]
DMSO: Sparingly soluble: 1-10 mg/ml
Ethanol: Sparingly soluble: 1-10 mg/ml |
| Hazard Information | Back Directory | [Uses]
WYneC can specifically bind to sulfinylated proteins in living cells and then react with fluorescent probes containing azide groups for detection. In the field of redox biology, WYneC can also be used to determine the occupancy of S-sulfinylation sites or as a carrier to deliver substances to mitochondria[1][2]. | [References]
[1] Yunlong Shi, et al. Wittig reagents for chemoselective sulfenic acid ligation enables global site stoichiometry analysis and redox-controlled mitochondrial targeting. Nat Chem. 2021 Nov;13(11):1140-1150. DOI:10.1038/s41557-021-00767-2
[2] Ji-Xiang He, et al. A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. DOI:10.1038/s41589-022-01074-8 |
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