| Identification | Back Directory | [Name]
2-fluoro-araATP | [CAS]
74832-57-8 | [Synonyms]
2-fluoro-araATP
Fludarabine triphosphate trisodium
9H-Purin-6-amine, 2-fluoro-9-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-arabinofuranosyl]- | [Molecular Formula]
C10H15FN5O13P3 | [MDL Number]
MFCD00872150 | [MOL File]
74832-57-8.mol | [Molecular Weight]
525.17 |
| Chemical Properties | Back Directory | [Boiling point ]
1006.2±75.0 °C(Predicted) | [density ]
2.68±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
0.97±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Fludarabine triphosphate (F-ara-ATP), the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC50 of 2.3 μM and a Ki of 6.1 μM. Fludarabine triphosphate inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis[1][2]. | [References]
[1] Catapano CV, et al. Inhibition of primer RNA formation in CCRF-CEM leukemia cells by fludarabine triphosphate. Cancer Res. 1991 Apr 1;51(7):1829-35. PMID:1706219
[2] Woodahl EL, et al. A novel phenotypic method to determine fludarabine triphosphate accumulation in T-lymphocytes from hematopoietic cell transplantation patients. Cancer Chemother Pharmacol. 2009 Feb;63(3):391-401. DOI:10.1007/s00280-008-0748-0 |
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