| Identification | Back Directory | [Name]
16(R)-Iloprost | [CAS]
74843-13-3 | [Synonyms]
16(R)-Iloprost
HIFJCPQKFCZDDL-GBSCXWAGSA-N | [Molecular Formula]
C22H32O4 | [MDL Number]
MFCD18432680 | [MOL File]
74843-13-3.mol | [Molecular Weight]
360.487 |
| Chemical Properties | Back Directory | [Boiling point ]
539.2±50.0 °C(Predicted) | [density ]
1.210±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 1 mg/ml | [pka]
4.77±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to the recombinant human IP and EP1 receptors with a Ki value of 11 nM. Most preparations of iloprost contain 16(S) and 16(R) stereoisomers. 16(R)-Iloprost inhibits platelet aggregation with an IC50 value of 65 nM. | [Uses]
16-(R)-Iloprost is the R-isomer of Iloprost (I267300), a synthetic analogue of Prostacyclin (PGI2) used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud's phenomenon and ischemia. | [Uses]
16-(R)-Iloprost is the R-isomer of Iloprost (I267300), a synthetic analogue of Prostacyclin (PGI2) used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud''s phenomenon and ischemia. | [References]
[1] K SCHR?R. The antiplatelet and cardiovascular actions of a new carbacyclin derivative (ZK 36 374)–equipotent to PGI2 in vitro.[J]. Naunyn-Schmiedeberg’s archives of pharmacology, 1981, 316 3: 252-255. DOI: 10.1007/bf00505658
[2] AH-LIM TSAI Kenneth K W Hadassah Vijjeswarapu. Interaction between platelet receptor and iloprost isomers[J]. Biochimica et biophysica acta. Biomembranes, 1988, 942 2: Pages 220-226. DOI: 10.1016/0005-2736(88)90023-5 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|