| Identification | Back Directory | [Name]
3-(2-AMINO-ETHYL)-1H-INDOLE-5-CARBOXYLIC ACID AMIDE | [CAS]
74885-09-9 | [Synonyms]
5-CT
5-CAT
5-carboxamidotryptamine
2-Carboxyamidotryptamine
5-Carboxyamidotryptamine
5-Carboxamide tryptamine
5-CARBOXAMINODOTRYPTAMINE
3-(2-Aminoethyl)-1H-indole-5-carboxamide
1H-Indole-5-carboxamide, 3-(2-aminoethyl)-
3-(2-AMINO-ETHYL)-1H-INDOLE-5-CARBOXYLIC ACID AMIDE
5-CARBOXAMIDOTRYPTAMINE HEMIETHANOLATE MALEATE SALT | [Molecular Formula]
C11H13N3O | [MDL Number]
MFCD02258957 | [MOL File]
74885-09-9.mol | [Molecular Weight]
203.24 |
| Chemical Properties | Back Directory | [Boiling point ]
513.6±35.0 °C(Predicted) | [density ]
1.293±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
H2O: 10 mg/mL | [form ]
solid | [pka]
16.32±0.30(Predicted) | [color ]
white or off-white | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
5-Carboxamidotryptamine maleate is an agonist of the 5-HT1 receptors. | [Definition]
ChEBI: 5-carboxamidotryptamine is a member of tryptamines. | [in vivo]
5-Carboxamidotryptamine (0.03-3 mg/kg i.p. and 0.125-5 μg i.c.v.) causes a dose-dependent reduction in rectal temperature of mice[3].
5-Carboxamidotryptamine (0.1-1 mg/kg; i.p.) reduces rectal temperature in wild type mice but not 5-HT7 receptor knockout mice[3].
5-Carboxamidotryptamine (0.0 1-1 μg/kg; i.v.) causes consistent, dose-related decreases in diastolic blood pressure and carotid arterial vascular resistance and increases in heart rate of cats. In contrast, 5-HT (1-100 μg/kg; i.v.) causes tachycardia but variable and complex effects on diastolic blood pressure and carotid arterial vascular resistance[5].
5-Carboxamidotryptamine does not cause bronchoconstriction in cats. In contrast, 5-HT causes dose-related bronchoconstriction[5]. | Animal Model: | Male Swiss Webster mice (20-25 g)[3] | | Dosage: | 0.03-3 mg/kg (i.p.) and 0.125-5 μg (i.c.v.) | | Administration: | i.p. and i.c.v. | | Result: | Caused dose-dependent reduction in rectal temperature. |
| Animal Model: | 5-HT7 receptor knockout mice (background=50% 129SvEv/50% C57Bl/6J)[3] | | Dosage: | 0.1-1 mg/kg | | Administration: | i.p. and i.c.v. | | Result: | Reduced rectal temperature in wild type but not 5-HT7 receptor knockout mice. |
| [IC 50]
5-HT1A Receptor; 5-HT1B Receptor; 5-HT1D Receptor; 5-HT5A Receptor; 5-HT7 Receptor |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
MOLEKULA Ltd.
|
| Tel: |
+44 (0) 1747 831066 |
| Website: |
www.molekula.co.uk |
| Company Name: |
SIGMA-RBI
|
| Tel: |
800 736 3690 (Orders) |
| Website: |
www.sigma-aldrich.com |
|