| Identification | Back Directory | [Name]
Handle region peptide (HRP),rat | [CAS]
749227-53-0 | [Synonyms]
Handle region peptide, rat
Handle region peptide (HRP),rat
L-Valine, L-arginyl-L-isoleucyl-L-leucyl-L-leucyl-L-lysyl-L-lysyl-L-methionyl-L-prolyl-L-seryl-
(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-6-amino-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S,3S)-2-[(2S)-2-amino-5-[(diaminomethylidene)amino]pentanamido]-3-methylpentanamido]-4-methylpentanamido]-4-methylpentanamido]hexanamido]hexanamido]-4-(methylsulfanyl)butanoyl]pyrrolidin-2-yl]formamido}-3-hydroxypropanamido]-3-methylbutanoic acid | [Molecular Formula]
C54H101N15O12S | [MDL Number]
MFCD10567247 | [MOL File]
749227-53-0.mol | [Molecular Weight]
1184.54 |
| Hazard Information | Back Directory | [Uses]
Handle region peptide, rat is a prorenin receptor antagonist, suppresses the progression of diabetic nephropathy and has anti-inflammatory in the eye. | [in vivo]
Handle region peptide, rat (0.1 mg/kg) suppresses leukocyte adhesion in the endotoxin-induced uveitis (EIU) retina, and decreases the leukocyte counts in rats. Handle region peptide, rat (0.1 mg/kg) lowers the protein concentration in EIU rats induced by LPS, and reduces the mRNA expression and the protein levels of inflammatory mediators such as ICAM-1, CCL2/MCP-1, and IL-6 in rats[2]. | [References]
[1] He M, et al. Inhibition of renin/prorenin receptor attenuated mesangial cell proliferation and reduced associated fibrotic factor release. Eur J Pharmacol. 2009 Mar 15;606(1-3):155-61. DOI:10.1016/j.ejphar.2008.12.050
[2] Satofuka S, et al. Suppression of ocular inflammation in endotoxin-induced uveitis by inhibiting nonproteolytic activation of prorenin. Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2686-92. DOI:10.1167/iovs.05-1458 |
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Ontores Biotech
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www.ontoresinc.cn |
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