| Identification | Back Directory | [Name]
Temarotene | [CAS]
75078-91-0 | [Synonyms]
AROTINOID
Ro-15-0778
Temarotene
Temaroteno
Temarotenum
Temaroteno [spanish]
1,2,3,4-Tetrahydro-1,1,4,4-tetramethyl-6-((E)-alpha-methylstyryl)naphthalene
1,2,3,4-Tetrahydro-1,1,4,4-tetramethyl-6-[(E)-1-methyl-2-phenylethenyl]naphthalene
Naphthalene, 1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-((1E)-1-methyl-2-phenylethenyl)-
Naphthalene, 1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-(1-methyl-2-phenylethenyl)-, (E)- | [Molecular Formula]
C23H28 | [MOL File]
75078-91-0.mol | [Molecular Weight]
304.47 |
| Chemical Properties | Back Directory | [Boiling point ]
403.3±40.0 °C(Predicted) | [density ]
0.963±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO |
| Hazard Information | Back Directory | [Uses]
Temarotene is an orally administered, particular arotinoid[1]. | [in vivo]
The aim of this preliminary report is to measure plasma and skin concentrations of Ro 15-0778 and its phenolic metabolite Ro 14-6113 in hairless rats receiving orally 10 mg/kg of Temarotene once daily during 10 days. Blood (2-3 mL) and skin (200-300 mg) samples are taken at different time points between 0.5 and 240 h after the last dose. A highly sensitive HPLC method is used for simultaneous determination of the two compounds with a quantification limit of 2 ng/mL in plasma and 10 ng/g in total skin (epidermis and dermis). After 10 h, plasma concentrations of Ro 14-6113 are 5-13 times higher than for Ro 15-0778. Ro 14-6113 concentrations in the skin are 4-10 times higher than for Ro 15-0778 within the initial 48 h. The concentrations of both compounds in the skin are higher than concentrations in plasma[1]. | [storage]
Store at -20°C | [References]
[1] Olsen DR, et al. Suppression of ornithine decarboxylase gene expression by retinoids in cultured human keratinocytes. J Invest Dermatol. 1990 Jan;94(1):33-6. DOI:10.1111/1523-1747.ep12873328
[2] Fenina N, et al. Concentration of Temarotene (Ro 15-0778) and its metabolite Ro 14-6113 in plasma and skin of hairless rat. Skin Pharmacol. 1993;6(1):61-4. DOI:10.1159/000211088 |
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