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75078-91-0

75078-91-0 Structure

75078-91-0 Structure
IdentificationBack Directory
[Name]

Temarotene
[CAS]

75078-91-0
[Synonyms]

AROTINOID
Ro-15-0778
Temarotene
Temaroteno
Temarotenum
Temaroteno [spanish]
1,2,3,4-Tetrahydro-1,1,4,4-tetramethyl-6-((E)-alpha-methylstyryl)naphthalene
1,2,3,4-Tetrahydro-1,1,4,4-tetramethyl-6-[(E)-1-methyl-2-phenylethenyl]naphthalene
Naphthalene, 1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-((1E)-1-methyl-2-phenylethenyl)-
Naphthalene, 1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-(1-methyl-2-phenylethenyl)-, (E)-
[Molecular Formula]

C23H28
[MOL File]

75078-91-0.mol
[Molecular Weight]

304.47
Chemical PropertiesBack Directory
[Boiling point ]

403.3±40.0 °C(Predicted)
[density ]

0.963±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
Hazard InformationBack Directory
[Uses]

Temarotene is an orally administered, particular arotinoid[1].
[in vivo]

The aim of this preliminary report is to measure plasma and skin concentrations of Ro 15-0778 and its phenolic metabolite Ro 14-6113 in hairless rats receiving orally 10 mg/kg of Temarotene once daily during 10 days. Blood (2-3 mL) and skin (200-300 mg) samples are taken at different time points between 0.5 and 240 h after the last dose. A highly sensitive HPLC method is used for simultaneous determination of the two compounds with a quantification limit of 2 ng/mL in plasma and 10 ng/g in total skin (epidermis and dermis). After 10 h, plasma concentrations of Ro 14-6113 are 5-13 times higher than for Ro 15-0778. Ro 14-6113 concentrations in the skin are 4-10 times higher than for Ro 15-0778 within the initial 48 h. The concentrations of both compounds in the skin are higher than concentrations in plasma[1].

[storage]

Store at -20°C
[References]

[1] Olsen DR, et al. Suppression of ornithine decarboxylase gene expression by retinoids in cultured human keratinocytes. J Invest Dermatol. 1990 Jan;94(1):33-6. DOI:10.1111/1523-1747.ep12873328
[2] Fenina N, et al. Concentration of Temarotene (Ro 15-0778) and its metabolite Ro 14-6113 in plasma and skin of hairless rat. Skin Pharmacol. 1993;6(1):61-4. DOI:10.1159/000211088
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