| Identification | Back Directory | [Name]
1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL | [CAS]
75144-12-6 | [Synonyms]
Antitrypanosomal agent 1
1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL
1-(3,4-Dichlorophenyl)-3-dimethylamino-1-propanonehydrochloride
1-(3,4-dichlorophenyl)-3-(dimethylamino)propan-1-one hydrochloride | [Molecular Formula]
C11H13Cl2NO.ClH | [MDL Number]
MFCD01220371 | [MOL File]
75144-12-6.mol | [Molecular Weight]
282.59 |
| Chemical Properties | Back Directory | [Melting point ]
186 - 188°C | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
Off-White | [Water Solubility ]
Water: 10 mg/mL (35.39 mM) |
| Hazard Information | Back Directory | [Uses]
Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor with an IC50 of 3.3 μM. Antitrypanosomal agent 1 inhibits glutathione reductase (GR) (IC50=64.8 μM) and T. brucei (EC50=1 μM). Antitrypanosomal agent 1 has anti-trypanosomal activity[1]. | [Biological Activity]
Antitrypanosomal agent 1 is a potent and selective inhibitor of trypanothione reductase with IC50 of 3.3 μM. It inhibits glutathione reductase with IC50 of 64.8 μM; inhibits Trypanosoma brucei with EC50 of 1 μM. It has antitrypanosomal activity. | [in vitro]
Antitrypanosomal agent 1 (compound 8a) has an selectivity for TR (GR IC50/TR IC50) of 20. | [target]
IC50: 3.3 μM (trypanothione reductase) and 64.8 μM (glutathione reductase)
EC50: 1 μM ( T. brucei ) | [storage]
Store at -20°C | [References]
[1] Martyn DC, et al. High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1280-3. DOI:10.1016/j.bmcl.2006.12.016 |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Rhawn Reagent
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| Telephone: |
400-400-1332688 18019345275 |
| Website: |
http://www.rhawn.cn |
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