| Identification | Back Directory | [Name]
N-NITROSO-L-PROLINE | [CAS]
7519-36-0 | [Synonyms]
NPRO
no-pro
Nsc109545
nitrosoproline
1-Nitrosoproline
N-NITROSO-PROLINE
N-NITROSO-L-PROLINE
1-nitroso-l-proline
L-Proline, nitroso-
L-Proline, 1-nitroso- | [Molecular Formula]
C5H8N2O3 | [MDL Number]
MFCD01698777 | [MOL File]
7519-36-0.mol | [Molecular Weight]
144.13 |
| Chemical Properties | Back Directory | [Appearance]
Colourless Plates | [Melting point ]
108-109°C | [Boiling point ]
262.71°C (rough estimate) | [density ]
1.4054 (rough estimate) | [refractive index ]
1.4472 (estimate) | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Sparingly) | [form ]
Solid | [pka]
3.23±0.20(Predicted) | [color ]
Pale Yellow to Brown | [IARC]
3 (Vol. 17, Sup 7) 1987 |
| Hazard Information | Back Directory | [Chemical Properties]
Colourless Plates | [Uses]
A nitrosoamino acid with oncogenic activity. The LD50 of a single ip dose given to Swiss-Webster mice is 203 +/- 22 mg / kg. | [Uses]
A nitrosoamino acid with oncogenicity. The LD50 of a single ip dose given to Swiss-Webster mice is 203 +/- 22 mg / kg | [Definition]
ChEBI: N-Nitrosoproline is a L-proline derivative. | [Production Methods]
There is no indication that nitrosoproline was made commercially.
It has been reported in cured meats (e.g., bacon) at
concentrations of 340–440 μg/kg. Both higher and
lower levels in several cured products have been reported
by several authors. | [Safety Profile]
Poison by intraperitoneal route.Questionable carcinogen with experimental tumorigenicdata. Many nitroso compounds are carcinogens. Whenheated to decomposition it emits toxic fumes of NOx. Seealso NITROSO COMPOUNDS. | [Carcinogenicity]
Mice were given 0.1% NPRO in drinking water for 26 weeks,
and no more lung adenomas were seen than in untreated
controls at 38 weeks, showing a lack of carcinogenicity.
In rats, higher doses (0.145%) in drinking water for 2 years
showed no tumors that were not seen in untreated controls
(174). IARC classified NPRO as not classifiable as
to carcinogenicity to humans (Group 3). |
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