| Identification | Back Directory | [Name]
1H-1,5-Benzodiazepine, 4-(4-chlorophenyl)-2,3-dihydro-2-phenyl- | [CAS]
75220-84-7 | [Synonyms]
Anticonvulsant agent 2 1H-1,5-Benzodiazepine, 4-(4-chlorophenyl)-2,3-dihydro-2-phenyl- | [Molecular Formula]
C21H17ClN2 | [MOL File]
75220-84-7.mol | [Molecular Weight]
332.83 |
| Chemical Properties | Back Directory | [Melting point ]
129-130 °C | [Boiling point ]
492.2±45.0 °C(Predicted) | [density ]
1.20±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
6.10±0.60(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Anticonvulsant agent 2 is a potent and orally active anticonvulsant agent. Anticonvulsant agent 2 shows antiepileptic activity[1]. | [in vivo]
Anticonvulsant agent 2 (compound10 a; 50 mg/kg, p.o.) decreases locomotor activity with an inhibition rate of 21.01% in rat[1]. Anticonvulsant agent 2 (50 mg/kg; p.o.) shows antiepileptic activity with an inhibition rate of 24.45% in rat[1]. | Animal Model: | 180-250g, male Wistar rats[1] | | Dosage: | 50 mg/kg | | Administration: | P.o. | | Result: | Showed antiepileptic activity with the inhibition rate of 24.45%. |
| [References]
[1] Verma R, et al. Design, synthesis and neuropharmacological evaluation of new 2,4-disubstituted-1,5-benzodiazepines as CNS active agents. Bioorg Chem. 2020 Aug;101:104010. DOI:10.1016/j.bioorg.2020.104010 |
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