| Chemical Properties | Back Directory | [form ]
Solid | [color ]
White to off-white | [Sequence]
Ile-Arg-Cys-Ser-Gly-Ser-Arg-Asp-Cys-Tyr-Ser-Pro-Cys-Met-Lys-Gln-Thr-Gly-Cys-Pro-Asn-Ala-Lys-Cys-Ile-Asn-Lys-Ser-Cys-Lys-Cys-Tyr-Gly-Cys-NH2 (Disulfide bridge: Cys3-Cys24, Cys9-Cys29, Cys13-Cys31, Cys19-Cys34) |
| Hazard Information | Back Directory | [Uses]
Spinoxin isolated from the venom of scorpion Heterometrus spinifer, is a 34-residue peptide neurotoxin cross-linked by four disulfide bridges. Spinoxin is a potent inhibitor of Kv1.3 potassium channel (IC50 = 63 nM), considering to be valid molecular targets in the diagnostics and therapy of various autoimmune disorders and cancers[1]. | [IC 50]
Kv1.3: 63 nM (IC50) | [References]
[1] Steve Peigneur, et al. Active Sites of Spinoxin, a Potassium Channel Scorpion Toxin, Elucidated by Systematic Alanine Scanning. Biochemistry. 2016 May 31;55(21):2927-35. DOI:10.1021/acs.biochem.6b00139 |
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Alomone Labs
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www.alomone.com |
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