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753024-08-7

753024-08-7 Structure

753024-08-7 Structure
IdentificationBack Directory
[Name]

A8SGLP-1
[CAS]

753024-08-7
[Synonyms]

A8SGLP-1
[Molecular Formula]

C151H229N41O47
[MOL File]

753024-08-7.mol
[Molecular Weight]

3370.69
Chemical PropertiesBack Directory
[density ]

1.490±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[solubility ]

DMSO: Sparingly Soluble: 1-10 mg/ml
Ethanol: Soluble: =10 mg/mlPBS (pH 7.2): Sparingly Soluble: 1-10 mg/ml
[Sequence]

His-Ser-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly-NH2
Hazard InformationBack Directory
[Uses]

A8SGLP-1 is an orally active GLP-1 analogue that the alanine at position 8 substituted with serine. A8SGLP-1 reduces blood glucose in db/db mice without affecting its function[1].
[References]

[1] Hanlin Zhang, et al. Oral glucagon-like peptide 1 analogue ameliorates glucose intolerance in db/db mice. Biotechnol Lett. 2022 Oct;44(10):1149-1162. DOI:10.1007/s10529-022-03288-1
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