| Identification | Back Directory | [Name]
4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline | [CAS]
75483-04-4 | [Synonyms]
AI-1
AI-1 >=98% (HPLC)
Nrf2 Activator II, AI-1
AI-1
(Nrf2 acticatior AI-1)
Nrf2 Activator II, AI-1 - CAS 75483-04-4 - Calbiochem
4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline
Ethyl 4-chloro-1,2-dihydro-1-methyl-2-oxoquinoline-3-carboxylate
4-Chloro-1,2-dihydro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester | [Molecular Formula]
C13H12ClNO3 | [MDL Number]
MFCD00634787 | [MOL File]
75483-04-4.mol | [Molecular Weight]
265.69 |
| Chemical Properties | Back Directory | [Melting point ]
90-92 °C | [Boiling point ]
358.7±42.0 °C(Predicted) | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥15mg/mL | [form ]
powder | [pka]
-2.22±0.60(Predicted) | [color ]
white to tan | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. | [InChI]
1S/C13H12ClNO3/c1-3-18-13(17)10-11(14)8-6-4-5-7-9(8)15(2)12(10)16/h4-7H,3H2,1-2H3 | [InChIKey]
XUJQDJGGHFNYDY-UHFFFAOYSA-N | [SMILES]
Clc1c2c([n]([c](c1C(=O)OCC)=O)C)cccc2 |
| Hazard Information | Back Directory | [Description]
AI-1 (75483-04-4) is a novel antioxidant response element (ARE) activator which activates Nrf2 by covalently modifying Keap1 (Kelch-like ECH-associated protein 1) a negative regulator of Nrf2. Modification of Cys151 of Keap1 by AI-1 disrupts the ability of Keap1 to serve as an adaptor for Cul3-Keap1 ubiquitin ligase complex, thereby stabilizing and inducing transcriptional activation of Nrf2. AI-1 is a useful pharmacological tool for probing the involvement of Nrf2 in cellular physiology.1?Cell permeable. | [Uses]
AI-1 is an antioxidant response element (ARE) that activates Nrf2 by covalently modifying Keap1. AI-1 is a useful pharmacological probe for investigating the molecular details of the cellular antioxidant response. | [References]
1) Hur?et al. (2010),?A small-molecule inducer of the antioxidant response element; Chem. Biol.,?17?537 |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck Millipore
|
| Tel: |
1-400-889-1988 400-889-1988 |
| Website: |
http://www.merckmillipore.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
TargetMol
|
| Tel: |
400-821-0310 15002144251 |
| Website: |
www.targetmol.cn/ |
|