| Identification | Back Directory | [Name]
Argpressin acetate | [CAS]
75499-44-4 | [Synonyms]
Argpressin acetate
Arginine Vasopressin Diacetate
Argpressin(Argipressin) acetate | [Molecular Formula]
C48H69N15O14S2 | [MOL File]
75499-44-4.mol | [Molecular Weight]
1144.29 |
| Chemical Properties | Back Directory | [Melting point ]
>166°C (dec.) | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
An endogenous antidiuretic hormone in most mammalian species. Arginine Vasopressin Diacetate is released into the blood from nerve terminals in the posterior pituitary and median eminence. It is a neurotransmitter in the central nervous system and also implicated in a variety of physiological processes such as regulating water balance by antidiuretic action. Arginine Vasopressin Diacetate is a peptidic V1a receptor agonist that produces vasoconstrictio n via V1aR-mediated vascular smooth muscle cell contraction and is being used to increase blood pressure in septic shock, a form of vasodilatory hypotension.
| [in vivo]
Argipressin (diacetate) (AVP (diacetate)) (25 nmol/kg bw; intraperitoneal injection; once) significantly reduces overall AUC glucose values, but not increases insulin levels in mice[1]. | Animal Model: | NIH Swiss mice (adult; male; 12-14weeks) [1] | | Dosage: | 25 nmol/kg bw | | Administration: | AVP (25 nmol/kg bw; intraperitoneal injection; once) | | Result: | Reduced (P<0.001) overall AUC glucose values，but not increased insulin levels in mice. |
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