| Identification | Back Directory | [Name]
K6PC-5 | [CAS]
756875-51-1 | [Synonyms]
K6PC-5
K6PC-5 >=98% (HPLC)
DIHYDROXYISOPROPYL CAPRYLOYLCAPRYLAMIDE
Decanamide, 2-hexyl-N-[2-hydroxy-1-(hydroxymethyl)ethyl]-3-oxo- | [Molecular Formula]
C19H37NO4 | [MDL Number]
MFCD30480923 | [MOL File]
756875-51-1.mol | [Molecular Weight]
343.5 |
| Chemical Properties | Back Directory | [Boiling point ]
555.3±50.0 °C(Predicted) | [density ]
1.007±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: 30 mg/ml | [form ]
A solid | [pka]
12.57±0.59(Predicted) | [color ]
White to off-white | [Cosmetics Ingredients Functions]
SKIN PROTECTING | [InChIKey]
CGYVFCHCRBGGJG-UHFFFAOYSA-N | [SMILES]
O=C(CCCCCCC)C(CCCCCC)C(NC(CO)CO)=O |
| Hazard Information | Back Directory | [Uses]
K6PC-5, a ceramide derivative, is a sphingosine kinase 1(SPHK1) activator and elicites a rapid transient increase in intracellular calcium levels. K6PC-5 has the potential for skin diseases involving abnormal keratinocyte, and neurodegeneration and virus infection research[1][2][3]. | [Biological Activity]
K6PC-5 is a potent and selective sphingosine kinase 1 (SphK1 or SK1) activator th at increases keratin 1 and involucrin expression in normal human epidermal keratinocytes cultured in vitro. K6PC-5 promotes differentiation and proliferation of keratinocytes via intracellular Ca2+ signaling. | [in vivo]
In intrinsically aged hairless mice (56 weeks old), 1% K6PC-5 is applied topically for 2 weeks. This K6PC-5 treatment significantly increases both the number of dermal fibroblasts and collagen production. As a consequence, dermal thickness also increased significantly[2]. | Animal Model: | Intrinsically aged hairless mice (56 weeks old)[2] | | Dosage: | 1% (vehicle (PEG:EtOH = 7:3)) | | Administration: | Topical application; twice daily for 2 weeks | | Result: | Enhanced fibroblast proliferation, collagen production, and eventually increased dermal thickness. |
| [IC 50]
SphK1; EBOV | [References]
[1] Kwon YB, et al. Novel synthetic ceramide derivatives increase intracellular calcium levels and promote epidermal keratinocyte differentiation. J Lipid Res. 2007 Sep;48(9):1936-43. DOI:10.1194/jlr.M700185-JLR200
[2] Jong-Kyung Youm, et al. K6PC-5, a sphingosine kinase activator, induces anti-aging effects in intrinsically aged skin through intracellular Ca2+ signaling. J Dermatol Sci. 2008 Aug;51(2):89-102. DOI:10.1016/j.jdermsci.2008.03.002
[3] Imre G, et al. The sphingosine kinase 1 activator, K6PC-5, attenuates Ebola virus infection. iScience. 2021 Mar 5;24(4):102266. DOI:10.1016/j.isci.2021.102266 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|