| Identification | Back Directory | [Name]
Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)- | [CAS]
757192-67-9 | [Synonyms]
EN106
Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)- | [Molecular Formula]
C13H13ClN2O3 | [MOL File]
757192-67-9.mol | [Molecular Weight]
280.71 |
| Chemical Properties | Back Directory | [Boiling point ]
489.1±45.0 °C(Predicted) | [density ]
1.351±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 250 mg/mL (890.60 mM; Need ultrasonic) | [form ]
Solid | [pka]
0.42±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
EN106 is a potent inhibitor of FEMIB. EN106 is a cysteine-reactive covalent ligand. EN106 disrupts recognition of the key reductive stress substrate of FEM1B, FNIP1[1]. | [Biological Activity]
EN106 is a cell-permeable covalent recruiter of CUL2 E3 ligase FEM1B th at binds to C186 of FEM1B. EN106 disrupts FEM1B interactions with the FNIP1 degron and inhibits CUL2FEM1B-dependent ubiquitylation without detectable off-target effects. A modified EN106 bifunctional analog (PROTAC) recruits FEM1B and induces targeted BRD4 and BCR-ABL/c-ABL degradation. | [References]
[1] Henning NJ, et al. Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications. J Am Chem Soc. 2022;144(2):701-708. DOI:10.1021/jacs.1c03980 |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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