| Identification | Back Directory | [Name]
H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-OH | [CAS]
75790-53-3 | [Synonyms]
Ph-8p
YGGFLRRI
dynorphin(1-8
DYNORPHIN A (1-8)
GFL PEPTIDE STANDARD
Dynorphin A(1-8)【rat】
Dynorphin A(1-8)【human】
DYNORPHIN A (1-8), PORCINE
TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE
DYNORPHIN A PORCINE FRAGMENT 1-8
Dynorphin A (1-8), porcine,YGGFLRRI
H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-OH
8-L-Isoleucine-1-8-dynorphin B (swine)
1-8-Dynorphin B (swine), 8-L-isoleucine-
dynorphin A fragment 1-8 porcine*sequence
L-Tyr-Gly-Gly-L-Phe-L-Leu-L-Arg-L-Arg-L-Ile-OH
L-Tyr-Gly-Gly-L-Phe-L-Leu-L-Arg-L-Arg-L-Pro-OH
DYNORPHIN A (1-8) SYNTHETIC >97% OPIOID AGONIST
Tyrosyl-glycyl-glycyl-phenylalanyl-leucyl-arginyl-arginyl-isoleucine
alpha-Neoendorphin, 7-L-arginine-8-L-isoleucine-9-de-L-proline-10-de-L-lysine-
Dynorphin A (1-8) acetate salt H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-OH acetate salt
L-Isoleucine, N-(N(2)-(N(2)-(N-(N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)-L-leucyl)-L-arginyl)-L-arginyl)- | [Molecular Formula]
C46H72N14O10 | [MDL Number]
MFCD00076357 | [MOL File]
75790-53-3.mol | [Molecular Weight]
981.17 |
| Chemical Properties | Back Directory | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
3.38±0.10(Predicted) | [color ]
White to off-white | [Sequence]
Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile |
| Hazard Information | Back Directory | [Uses]
Dynorphin A (1-8) is the predominant opioid peptide identified in placental tissue extracts. Dynorphin A (1-8) is the most likely natural ligand of the kappa receptor. The binding of 3H-Bremazocine to the purified kappa receptor is inhibited by Dynorphin A (1-8) (IC50=303 nM)[1][2]. | [IC 50]
κ Opioid Receptor/KOR; Human Endogenous Metabolite | [References]
[1] Agbas A, Ahmed MS, Millington W, et al. Dynorphin A(1-8) in human placenta: amino acid sequence determined by tandem mass spectrometry. Peptides. 1995;16(4):623-627. DOI:10.1016/0196-9781(95)00013-a
[2] Ahmed MS, Zhou DH, Cavinato AG, Maulik D. Opioid binding properties of the purified kappa receptor from human placenta. Life Sci. 1989;44(13):861-871. DOI:10.1016/0024-3205(89)90586-9 |
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