| Identification | Back Directory | [Name]
1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 5-bromo- | [CAS]
757978-33-9 | [Synonyms]
5-BroMo-3-forMyl-7-azaindole
5-Bromo-7-azaindole-3-carboxaldehyde
5-Bromo-1H-pyrrolo pyridine-3-carbaldehyde
5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde
1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 5-bromo-
5-bromo-5,6-dihydro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde | [Molecular Formula]
C8H5BrN2O | [MDL Number]
MFCD09755969 | [MOL File]
757978-33-9.mol | [Molecular Weight]
225.04 |
| Chemical Properties | Back Directory | [density ]
1.830±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [pka]
11.42±0.40(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
(a) Step 1: Glacial acetic acid (0.2 mL), water (0.4 mL) and hexamethylenetetetramine (0.087 g, 0.62 mmol) were added sequentially to 5-bromo-7-azaindole (0.087 g, 0.44 mmol), and the reaction was carried out in a sealed tube with stirring at 120°C overnight. Upon completion of the reaction, water was added to the mixture and the precipitated solid was collected by filtration to afford 5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde (0.061 g, 62% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 8.46 (d, J = 2.2 Hz, 1H), 8.53 (d, J = 2.2 Hz, 1H), 8.54 (s, 1H), 9.93 (s, 1H). | [References]
[1] Patent: EP2565192, 2013, A1. Location in patent: Paragraph 0304
[2] Patent: US2015/259357, 2015, A1. Location in patent: Paragraph 1561 |
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