ChemicalBook--->CAS DataBase List--->75859-03-9

75859-03-9

75859-03-9 Structure

75859-03-9 Structure
IdentificationBack Directory
[Name]

9-[3-(CIS-3,5-DIMETHYL-1-PIPERAZINYL)PROPYL]-9H-CARBAZOLE DIHYDROCHLORIDE
[CAS]

75859-03-9
[Synonyms]

bw234u
Rimcazole
Rimcazole2HCl
Reaxys ID: 5785235
RIMCAZOLE DIHYDROCHLORIDE
9-[3-(3,5-dimethyl-1-piperazinyl)propyl]carbazole dihydrochloride
cis-9-(3-(3,5-dimethyl-1-piperazinyl)propyl)-9h-carbazoledihydrochloride
9-[3-(CIS-3,5-DIMETHYL-1-PIPERAZINYL)PROPYL]-9H-CARBAZOLE DIHYDROCHLORIDE
9-(3-(3,5-dimethyl-l-piperazinyl)propyl)-,dihydrochloride,cis-9h-carbazol
9-(3-(cis-3,5-Dimethylpiperazin-1-yl)propyl)-9H-carbazole dihydrochloride
[Molecular Formula]

C21H29Cl2N3
[MDL Number]

MFCD00083199
[MOL File]

75859-03-9.mol
[Molecular Weight]

394.38
Chemical PropertiesBack Directory
[storage temp. ]

Store at +4°C
[form ]

Powder
[color ]

White to off-white
[Water Solubility ]

Soluble to 10 mM in water
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H302-H335
[Precautionary statements ]

P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Hazard InformationBack Directory
[Uses]

Rimcazole Dihydrochloride is a small molecule antagonist of the σ-1 receptor and inhibits tumor cell survival.
[Biological Activity]

Antagonist at σ receptors (IC 50 values are 1480 and 386 nM at σ 1 and σ 2 receptors respectively). Also binds to the dopamine transporter (IC 50 = 57.6 nM) and inhibits dopamine uptake. Reduces the stimulatory effects of cocaine in vivo .
[storage]

Store at +4°C
Spectrum DetailBack Directory
[Spectrum Detail]

9-[3-(CIS-3,5-DIMETHYL-1-PIPERAZINYL)PROPYL]-9H-CARBAZOLE DIHYDROCHLORIDE(75859-03-9)1HNMR
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