| Identification | Back Directory | [Name]
TARAXINICACID | [CAS]
75911-33-0 | [Synonyms]
TARAXINICACID
Taraxinic acid β-D-glucopyranosyl
(3aS,6Z,10E,11aR)-2,3,3a,4,5,8,9,11a-Octahydro-10-methyl-3-methylene-2-oxocyclodeca[b]furan-6-carboxylic acid | [Molecular Formula]
C15H18O4 | [MOL File]
75911-33-0.mol | [Molecular Weight]
262.3 |
| Hazard Information | Back Directory | [Uses]
Taraxinic acid can be found in the roots of Taraxacum flavostylum and Taraxacum lucidum. It is a Tyrosinase inhibitor that dose-dependently inhibits Tyrosinase activity, showing approximately 54.5% inhibition at a concentration of 50 μg/mL. Taraxinic acid has an IC50 of 83.2 μM against melanoma cells A375 and HTB140, and an IC50 of 60.4 μM against melanoma cells WM793, with activity being both dose- and time-dependent. Taraxinic acid holds promise for research in the field of anticancer therapy[1]. | [References]
[1] Park S I, et al. Tyrosinase inhibitory activity and melanin production inhibitory activity of taraxinic acid from Taraxacum coreanum[J]. Korean Journal of Plant Resources, 2021, 34(4): 368-376.
[2] Michalska K, et al. Further sesquiterpenoids and phenolics from two species of Taraxacum FH Wigg. and cytotoxic activity of taraxinic acid and its derivatives[J]. Phytochemistry Letters, 2019, 30: 296-301. |
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