ChemicalBook--->CAS DataBase List--->76-96-0

76-96-0

76-96-0 Structure

76-96-0 Structure
IdentificationBack Directory
[Name]

1,1',1''-phosphorothioyltris(2-methylaziridine)
[CAS]

76-96-0
[Synonyms]

ENT 161A
NSC 56843
NSC 54055
Metapside
Methiotepa
Tris(2-methyl-1-aziridinyl)phosphine sulfide
1,1',1''-phosphorothioyltris(2-methylaziridine)
tris(2-methylethylenimin-1-yl)-thioxo-phosphorane
tris(2-methylaziridin-1-yl)-sulfanylidene-$l^{5}-phosphane
[EINECS(EC#)]

200-995-3
[Molecular Formula]

C9H18N3PS
[MOL File]

76-96-0.mol
[Molecular Weight]

231.3
Chemical PropertiesBack Directory
[Boiling point ]

294.4±23.0 °C(Predicted)
[density ]

1.30±0.1 g/cm3(Predicted)
[pka]

3.80±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

Methiotepa is a trifunctional aziridine chemosterilant.
[Production Methods]

Methiotepa was produced commercially through the synthesis of tris(1 aziridinyl)phosphine sulphide, an organophosphorus compound. Industrial manufacture involved reacting phosphorus sulphide derivatives with aziridine under controlled conditions, allowing three aziridine groups to attach to the phosphorus center. The process required strict regulation of temperature and solvent environment to prevent polymerisation and hazardous by products, as methiotepa is highly reactive and toxic.
[Mechanism of action]

Causes reproductive sterility in the pest
[Pesticide Type]

Insecticide
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