| Identification | Back Directory | [Name]
(R)-(-)-Nicardipine | [CAS]
76093-35-1 | [Synonyms]
(R)-(-)-Nicardipine
(R)-YC-93 free base
Nicardipine Impurity 13 ((R)-(+)-Nicardipine) | [Molecular Formula]
C26H29N3O6 | [MDL Number]
MFCD23704653 | [MOL File]
76093-35-1.mol | [Molecular Weight]
479.52 |
| Chemical Properties | Back Directory | [Boiling point ]
603.4±55.0 °C(Predicted) | [density ]
1.230±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 200 mg/mL (417.08 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [pka]
7.30±0.50(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
(R)-Nicardipine ((R)-YC-93 free base) is the less active R enantiomer of Nicardipine. Nicardipine (YC-93) is a calcium channel blocker with an IC50 of 1 μM for blocking cardiac calcium channels. Nicardipine acts as an agent for chronic stable angina and for controlling blood pressure[1]. | [Definition]
ChEBI: (R)-nicardipine is the R-enantiomer of nicardipine. It has a role as an antihypertensive agent and a calcium channel blocker. It is an enantiomer of a (S)-nicardipine. | [References]
[1] Charnet P, et al. Electrophysiological analysis of the action of nifedipine and nicardipine on myocardial fibers. Fundam Clin Pharmacol. 1987;1(6):413-31. DOI:10.1111/j.1472-8206.1987.tb00575.x |
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