| Identification | Back Directory | [Name]
KR-62436 | [CAS]
761414-79-3 | [Synonyms]
KR-62436 hydrate
3-Pyridinecarbonitrile, 6-[[2-[[2-(5-cyano-4,5-dihydro-1H-pyrazol-1-yl)-2-oxoethyl]amino]ethyl]amino]-
6-{2-[(5-Cyano-4,5-dihydropyrazol-1-yl)-2-oxoethylamino]ethylamino}nicotinonitrile dihydrochloride hydrate | [Molecular Formula]
C14H15N7O | [MDL Number]
MFCD17215675 | [MOL File]
761414-79-3.mol | [Molecular Weight]
297.32 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
H2O: 12 mg/mL | [form ]
powder | [color ]
white to beige | [Water Solubility ]
H2O: 5mg/mL, clear | [InChI]
1S/C14H15N7O.2ClH.H2O/c15-7-11-1-2-13(19-9-11)18-6-5-17-10-14(22)21-12(8-16)3-4-20-21;;;/h1-2,4,9,12,17H,3,5-6,10H2,(H,18,19);2*1H;1H2 | [InChIKey]
FQZOFSJMRKZMSV-UHFFFAOYSA-N | [SMILES]
O.Cl.Cl.O=C(CNCCNc1ccc(cn1)C#N)N2N=CCC2C#N |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22 | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral |
| Hazard Information | Back Directory | [Biochem/physiol Actions]
KR-62436 is a competitive inhibitor of dipeptidyl peptidase-IV (DPP-IV). DPP-IV is a serine protease which inactivates glucagon-like peptide (GLP-1); IC50 0.1-0.8 μM; GLP-1 is a potent stimulus for insulin secretion and inducer of satiety after food intake, but it has a very short action (1 min) because it is rapidly degraded by DPP-IV; blocking DPP-IV increases GLP-1 action and increases plasma insulin levels; DPP-IV inhibitors and KR-62436 have clinical potential as anti-diabetic agents |
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| Company Name: |
Merck KGaA
|
| Telephone: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|